Important Notes
The 'Bloody Ties' DLC and co-op are required for 100%.
Co-op is not the best aspect of the game, but it makes some Carnage Hall Show challenges trivial.
Avoid playing in New Game+ if possible, for a faster and easier run.
Some side quests disappear if you progress too far in the main story.
Most quests only appear when you get close to their location.
Use the paraglider and fast travel as little as possible for Ultramarathon.
Always stop what you do to save survivors during random encounters.
Keep 26 Inhibitor upgrades unused, back up your save, then fully upgrade Stamina and Health one after the other for Fit as a Fiddle and Ironheart to avoid a full NG+ run.
Useful Resources
Achievement summary with examples:
Missable quests guide:
Ironheart and Fit as a Fiddle detailed guide:
One Playthrough Optimization
Missable Quests
It is possible to complete everything in a single optimized playthrough without New Game+. However, you must carefully track side quests and collectibles. You don't have to do all missions, but some of them are require for achievements or collectables.
If you miss something, you have two possibilities:
Replay in New Game+.
Join another player’s world to complete their quests or grab collectibles.
Ironheart and Fit as a Fiddle Achievements
These require maxing out Health or Stamina. Normally, you can only fully max one in your first playthrough. All Inhibitors become available after completing both a normal run and New Game+.
To avoid a second full run, follow these steps (see the guide for more details):
Collect all Inhibitors.
Do not spend upgrade points immediately.
Back up your save when you have 26 points available.
Max either Health or Stamina for the achievement.
Reload your save and max the other one.
Without this method, you will need two near-complete playthroughs (Normal + New Game+).
Grind to Avoid
Ultramarathon requires traveling at least 960 km, but the paraglider and fast travel do not count. Walk, run, climb, grapple, and use ziplines instead.
Always save Survivors during random encounters for A Friend in Need.... Many online farming methods no longer work, but this one worked for me in 2025:
One million money (Who Wants To Be a...) can be achieved by selling and rebuying valuable items (or multiple items at once) in the late game.
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